Incremental prognostic value of immune cell densities beyond clinical parameters in non-small cell lung cancer
Nordling, Love; Backman, Max; Mezheyeuski, Artur; Lindblad, Joakim; et al.
Publications
Research outputs across the group
The group studies how cancer develops and responds to treatment within real tissue environments rather than in isolation. That perspective guides the work from hypothesis generation through translational application.
By building from deeply characterized lung and breast cancer cohorts and applying in situ and spatial methods, the lab connects single-cell biology with molecular and clinical context. Close integration with pathology, hospital-based workflows, and collaborative networks helps move discoveries toward diagnostic relevance and patient benefit.
Complete list
All publications
In situ mapping of activated PDGFRβ defines a prognostic discrepancy between histological subtypes of NSCLC
Lindberg, Amanda; Hellberg, Louise; Grandon, Anaïs; Yu, Hui; et al.
Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity
He, Liqun; Testini, Chiara; Hekmati, Neda; Bonello, Altea; et al.
Spatial TCR clonality and clonal expansion in the in situ microenvironment of non-small cell lung cancer
Yu, Hui; Magoulopoulou, Anastasia; Amini, Rose-Marie; Chatzinikolaou, Maria Paraskevi; et al.
In situ detection of PD1–PD-L1 interactions as a functional predictor for response to immune checkpoint inhibition in NSCLC
Lindberg, Amanda; Muhl, Lars; Yu, Hui; Hellberg, Louise; et al.
A comprehensive molecular atlas of the mesenchymal cell types in the mouse liver
Pietilä, Riikka; Genové, Guillem; Mocci, Giuseppe; Miao, Yuyang; et al.
scFFPE-ATAC enables high-throughput single cell chromatin accessibility profiling in formalin-fixed paraffin-embedded samples
Yadav, Ram Prakash; Xing, Pengwei; Zhao, Miao; Hollander, Peter; et al.
Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma
Biswas, Dhruva; Liu, Yun-Hsin; Herrero, Javier; Wu, Yin; et al.
The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma
Ohata, Yae; Ali, Mohamad M.; Tsubakihara, Yutaro; Itoh, Yuka; et al.
Unlocking novel T cell-based immunotherapy for hepatocellular carcinoma through neoantigen-driven T cell receptor isolation
Maravelia, Panagiota; Yao, Haidong; Cai, Curtis; Silva, Daniela Nascimento; et al.
An injury-associated lobular microniche is associated with the classical tumor cell phenotype in pancreatic cancer
Söderqvist, Sara; Viljamaa, Annika; Geyer, Natalie; Keller, Anna-Lena; et al.
Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial
Tullberg, Axel Stenmark; Thurfjell, Viktoria; Kovacs, Aniko; Micke, Patrick; et al.
Spatial distribution of tertiary lymphoid structures in the molecular and clinical context of non-small cell lung cancer.
Elfving, Hedvig; Yu, Hui; Kassete Fessehatsio, Kaleab; Brunnström, Hans; et al.
Predictors of survival and recurrence patterns following definitive chemoradiotherapy in stage III non-small cell lung cancer: a retrospective cohort study
Broström, Erika; Isaksson, Johan; Xanthoulis, Panagiotis; Börjesson, Rebecka; et al.
Gene expression-based identification of prognostic markers in lung adenocarcinoma
Salomonsson, Annette; Ehinger, Daniel; Jonsson, Mats; Botling, Johan; et al.
Functional and clinical roles of stromal PDGF receptors in tumor biology
Strell, Carina; Rodríguez-Tomàs, Elisabet; Östman, Arne
Diagnostic gastrointestinal markers in primary lung cancer and pulmonary metastases
Malmros, Karina; Lindholm, Andreas; Vidarsdottir, Halla; Jirström, Karin; et al.
The histological growth patterns in liver metastases from colorectal cancer display differences in lymphoid, myeloid, and mesenchymal cells
Garcia-Vicien, Gemma; Ruiz, Nuria; Micke, Patrick; Ruffinelli, Jose Carlos; et al.
Use of beta-blockers in patients with ductal carcinoma in situ and risk of invasive breast cancer recurrence: a Swedish retrospective cohort study
Strell, Carina; Smith, Daniel Robert; Valachis, Antonis; Woldeyesus, Hellen; et al.
Distinct microRNA Signature and Suppression of ZFP36L1 Define ASCL1-Positive Lung Adenocarcinoma
Enokido, Takayoshi; Horie, Masafumi; Yoshino, Seiko; Suzuki, Hiroshi I.; et al.
Tumor Heterogeneity Confounds Lymphocyte Metrics in Diagnostic Lung Cancer Biopsies
Elfving, Hedvig; Thurfjell, Viktoria; Mattsson, Johanna Sofia Margareta; Backman, Max; et al.
Phenotypic characterization of spatial immune infiltration niches in non-small cell lung cancer
Gerdtsson, Anna Sandström; Knulst, Mattis; Botling, Johan; Mezheyeuski, Artur; et al.
An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers
Mezheyeuski, Artur; Backman, Max; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso; et al.
Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features
Pellinen, Teijo; Paavolainen, Lassi; Martín-Bernabé, Alfonso; Papatella Araujo, Renata; et al.
Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer
Hikmet Noraddin, Feria; Rassy, Marc; Backman, Max; Méar, Loren; et al.
Vessel size as a marker of survival in estrogen receptor positive breast cancer
Milosevic, Vladan; Edelmann, Reidunn J.; Winge, Ingeborg; Strell, Carina; et al.
Spatial immunophenotyping of the tumour microenvironment in non-small cell lung cancer
Backman, Max; Strell, Carina; Lindberg, Amanda; Mattsson, Johanna S. M.; et al.
An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
Moro, Carlos Fernandez; Geyer, Natalie; Harrizi, Sara; Hamidi, Yousra; et al.
Matched Analyses of Brain Metastases versus Primary Non-Small Cell Lung Cancer Reveal a Unique microRNA Signature
Tsakonas, Georgios; Koulouris, Andreas; Kazmierczak, Dominika; Botling, Johan; et al.
A Novel Pancreatic Cancer Mini-tumor Model to Study Desmoplasia and Myofibroblastic Cancer-Associated Fibroblast Differentiation
Harryvan, T.J.; Hawinkels, L.J.A.C.; Inderson, A.; van Hooft, J.E.; et al.
Comparison of ROS1-rearrangement detection methods in a cohort of surgically resected non-small cell lung carcinomas
Thurfjell, Viktoria; Micke, Patrick; Yu, Hui; Krupar, Rosemarie; et al.
Highly elevated systemic inflammation is a strong independent predictor of early mortality in advanced non-small cell lung cancer
Isaksson, Johan; Wennström, Leo; Brandén, Eva; Koyi, Hirsh; et al.
Spatial Immunology in Liver Metastases from Colorectal Carcinoma according to the Histologic Growth Pattern
Garcia-Vicien, Gemma; Mezheyeuski, Artur; Micke, Patrick; Ruiz, Nuria; et al.
Prognostic Significance of the Loss of Heterozygosity of KRAS in Early-Stage Lung Adenocarcinoma
Khadse, Anand; Haakensen, Vilde D.; Silwal-Pandit, Laxmi; Hamfjord, Julian; et al.
Spatial genomics maps the structure, nature and evolution of cancer clones
Lomakin, Artem; Svedlund, Jessica; Strell, Carina; Gataric, Milana; et al.
Difficulties in diagnostics of lung tumours in biopsies: an interpathologist concordance study evaluating the international diagnostic guidelines
Ericson Lindquist, Kajsa; Ciornei, Cristina; Westbom-Fremer, Sofia; Gudinaviciene, Inga; et al.
Expression of cartilage oligomeric matrix protein in periampullary adenocarcinoma is associated with pancreatobiliary-type morphology, higher levels of fibrosis and immune cell exclusion
Papadakos, Konstantinos S.; Lundgren, Sebastian; Gialeli, Chrysostomi; Micke, Patrick; et al.
Tumour-infiltrating lymphocytes add prognostic information for patients with low-risk DCIS: findings from the SweDCIS randomised radiotherapy trial
Schiza, Aglaia; Thurfjell, Viktoria; Stenmark Tullberg, Axel; Olofsson, Helena; et al.
Plasma Proteomic Analysis in Non-Small Cell Lung Cancer Patients Treated with PD-1/PD-L1 Blockade
Eltahir, Mohamed; Isaksson, Johan; Mattsson, Johanna Sofia Margareta; Karre, Klas; et al.
The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types
Micke, Patrick; Strell, Carina; Mattsson, Johanna Sofia Margareta; Martin-Bernabe, Alfonso; et al.
Infiltration of NK and plasma cells is associated with a distinct immune subset in non‐small cell lung cancer
Backman, Max; La Fleur, Linnea; Kurppa, Pinja; Djureinovic, Dijana; et al.
PD-L1 amplification is associated with an immune cell rich phenotype in squamous cell cancer of the lung
Goldmann, Torsten; Marwitz, Sebastian; Nitschkowski, Dorte; Krupar, Rosemarie; et al.
Evaluation of NTRK immunohistochemistry as a screening method for NTRK gene fusion detection in non-small cell lung cancer
Elfving, Hedvig; Broström, Erika; Moens, Lotte N.J.; Almlöf, Jonas; et al.
Identification and functional characterization of new missense SNPs in the coding region of the TP53 gene
Doffe, Flora; Carbonnier, Vincent; Tissier, Manon; Leroy, Bernard; et al.
Plasma Proteome Fingerprints Reveal Distinctiveness and Clinical Outcome of SARS-CoV-2 Infection
Bauer, Wolfgang; Weber, Marcus; Diehl-Wiesenecker, Eva; Galtung, Noa; et al.
Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis
Yamaguchi, Yoko; Saito, Akira; Horie, Masafumi; Aoki, Akira; et al.
An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation
Sabatier, Pierre; Beusch, Christian M.; Saei, Amir A.; Aoun, Mike; et al.
Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation
Moreno-Ruiz, Pablo; Corvigno, Sara; te Grootenhuis, Nienke C.; La Fleur, Linnéa; et al.
FGFR1 overexpression in non-small cell lung cancer is mediated by genetic and epigenetic mechanisms and is a determinant of FGFR1 inhibitor response
Bogatyrova, Olga; Mattsson, Johanna S M; Ross, Edith M.; Sanderson, Michael P.; et al.
The Immune Landscape of Colorectal Cancer
Mezheyeuski, Artur; Micke, Patrick; Martin-Bernabe, Alfonso; Backman, Max; et al.
High Density of NRF2 Expression in Malignant Cells Is Associated with Increased Risk of CNS Metastasis in Early-Stage NSCLC
Tsakonas, Georgios; Martin-Bernabe, Alfonso; Rounis, Konstantinos; Moreno-Ruiz, Pablo; et al.
TGF-beta-mediated epithelial-mesenchymal transition and tumor-promoting effects in CMT64 cells are reflected in the transcriptomic signature of human lung adenocarcinoma
Miyashita, Naoya; Enokido, Takayoshi; Horie, Masafumi; Fukuda, Kensuke; et al.
Targeting MARCO and IL-37R on immunosuppressive macrophages in lung cancer blocks regulatory T cells and supports cytotoxic lymphocyte function
La Fleur, Linnea; Botling, Johan; He, Fei; Pelicano, Catarina; et al.
Stabilization of the classical phenotype upon integration of pancreatic cancer cells into the duodenal epithelium
Bozoky, Benedek; Moro, Carlos Fernandez; Strell, Carina; Geyer, Natalie; et al.
High PDGFRb Expression Predicts Resistance to Radiotherapy in DCIS within the SweDCIS Randomized Trial
Strell, Carina; Folkvaljon, Dick; Holmberg, Erik; Schiza, Aglaia; et al.
Programmed Cell Death Ligand 1 Expression in Resected Non-Small Cell Lung Cancer
Yu, Hui; Brustugun, Odd Terje; Ekman, Simon; Botling, Johan; et al.
The protein expression profile of ACE2 in human tissues
Noraddin, Feria Hikmet; Méar, Loren; Edvinsson, Åsa; Micke, Patrick; et al.
Comprehensive analysis of RNA binding motif protein 3 (RBM3) in non-small cell lung cancer
Salomonsson, Annette; Micke, Patrick; Mattsson, Johanna S M; La Fleur, Linnéa; et al.
Topographical Distribution and Spatial Interactions of Innate and Semi-Innate Immune Cells in Pancreatic and Other Periampullary Adenocarcinoma
Lundgren, Sebastian; Micke, Patrick; Elebro, Jacob; Heby, Margareta; et al.
The Novel Anti-cMet Antibody seeMet 12 Potentiates Sorafenib Therapy and Radiotherapy in a Colorectal Cancer Model
Spiegelberg, Diana; Lundgren Mortensen, Anja Charlotte; Palupi, Kartika Dyah; Micke, Patrick; et al.
Fibroblasts in urothelial bladder cancer define stroma phenotypes that are associated with clinical outcome
Mezheyeuski, Artur; Segersten, Ulrika; Leiss, Lina Wik; Malmström, Per-Uno; et al.
Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier
Zeitelhofer, Manuel; Adzemovic, Milena Z.; Moessinger, Christine; Stefanitsch, Christina; et al.
PD-L1 expression in gastroenteropancreatic neuroendocrine neoplasms grade 3
Ali, Abir Salwa; Langer, Seppo W.; Federspiel, Birgitte; Hjortland, Geir Olav; et al.
An immune gene expression signature distinguishes central nervous system metastases from primary tumours in non-small-cell lung cancer
Tsakonas, Georgios; Lewensohn, Rolf; Botling, Johan; Ortiz-Villalon, Cristian; et al.
Prognostic Interactions between FAP plus Fibroblasts and CD8a+T Cells in Colon Cancer
Herrera, Mercedes; Mezheyeuski, Artur; Villabona, Lisa; Corvigno, Sara; et al.
ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma
Miyashita, Naoya; Horie, Masafumi; Mikami, Yu; Urushiyama, Hirokazu; et al.
Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis
Kramer, Frederike; Dernedde, Jens; Mezheyeuski, Artur; Tauber, Rudolf; et al.
Quantitative, qualitative and spatial analysis of lymphocyte infiltration in periampullary and pancreatic adenocarcinoma
Lundgren, Sebastian; Elebro, Jacob; Heby, Margareta; Nodin, Björn; et al.
Multiplex plasma protein profiling identifies novel markers to discriminate patients with adenocarcinoma of the lung
Djureinovic, Dijana; Pontén, Victor; Landelius, Per; Al Sayegh, Sahar; et al.
Programmed Cell Death Ligand 1 Immunohistochemistry: A Concordance Study Between Surgical Specimen, Biopsy, and Tissue Microarray
Elfving, Hedvig; Mattsson, Johanna Sofia Margareta; Lindskog, Cecilia; Backman, Max; et al.
A combined gene expression tool for parallel histological prediction and gene fusion detection in non-small cell lung cancer
Karlsson, Anna; Cirenajwis, Helena; Ericson-Lindquist, Kajsa; Brunnström, Hans; et al.
Mucin staining is of limited value in addition to basic immunohistochemical analyses in the diagnostics of non-small cell lung cancer
Micke, Patrick; Botling, Johan; Mattsson, Johanna Sofia Margareta; Planck, Maria; et al.
A clonal expression biomarker associates with lung cancer mortality
Biswas, Dhruva; Birkbak, Nicolai J.; Rosenthal, Rachel; Hiley, Crispin T.; et al.
c-MET as a biomarker in patients with surgically resected non-small cell lung cancer
Tsakonas, Georgios; Botling, Johan; Micke, Patrick; Rivard, Chris; et al.
Immunohistochemical profiles in primary lung cancers and epithelial pulmonary metastases
Vidarsdottir, Halla; Tran, Lena; Nodin, Björn; Jirström, Karin; et al.
LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer
Cadenas, Cristina; Vosbeck, Sonja; Edlund, Karolina; Grgas, Katharina; et al.
Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC
Edlund, Karolina; Madjar, Katrin; Mattsson, Johanna Sofia Margareta; Djureinovic, Dijana; et al.
Real-world prevalence of programmed death ligand 1 expression in locally advanced or metastatic non small-cell lung cancer: The global, multicenter EXPRESS study
Dietel, M.; Savelov, N.; Salanova, R.; Micke, Patrick; et al.
NK- and T-cell subsets in malignant mesothelioma patients: Baseline pattern and changes in the context of anti-CTLA-4 therapy
Sottile, Rosa; Tannazi, Milad; Johansson, Maria H.; Cristiani, Costanza Maria; et al.
Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11
La Fleur, Linnea; Falk-Sörqvist, Elin; Smeds, Patrik; Berglund, Anders; et al.
Cancer stemness, intratumoral heterogeneity, and immune response across cancers
Miranda, Alex; Hamilton, Phineas T.; Zhang, Allen W.; Pattnaik, Swetansu; et al.
Multispectral imaging for quantitative and compartment-specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients
Mezheyeuski, Artur; Bergsland, Christian Holst; Backman, Max; Djureinovic, Dijana; et al.
Expression of scavenger receptor MARCO defines a targetable tumor-associated macrophage subset in non-small cell lung cancer
La Fleur, Linnea; Boura, Vanessa F.; Alexeyenko, Andrey; Berglund, Anders; et al.
The Heidelberg compact electron beam ion traps
Micke, Patrick; Kühn, S; Buchauer, L; Harries, J R; et al.
COX-2 expression and effects of celecoxib in addition to standard chemotherapy in advanced non-small cell lung cancer.
Gulyas, Miklos; Mattsson, Johanna Sofia Margareta; Lindgren, Andrea; Ek, Lars; et al.
Comparison of Three Different TTF-1 Clones in Resected Primary Lung Cancer and Epithelial Pulmonary Metastase
Vidarsdottir, Halla; Tran, Lena; Nodin, Björn; Jirström, Karin; et al.
LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease
Karlsson, Terese; Kvarnbrink, Samuel; Holmlund, Camilla; Botling, Johan; et al.
An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1-Positive Lung Adenocarcinomas
Miyashita, Naoya; Horie, Masafumi; Suzuki, Hiroshi I.; Yoshihara, Masahito; et al.
An integrative transcriptome analysis reveals a functional role for thyroid transcription factor-1 in small cell lung cancer
Horie, Masafumi; Miyashita, Naoya; Mattsson, Johanna Sofia Margareta; Mikami, Yu; et al.
Radionuclide Therapy of HER2-Expressing Human Xenografts Using Affibody-Based Peptide Nucleic Acid-Mediated Pretargeting: In Vivo Proof of Principle
Westerlund, Kristina; Altai, Mohamed; Mitran, Bogdan; Konijnenberg, Mark; et al.
Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer
Djureinovic, Dijana; Dodig-Crnkovic, Tea; Hellström, Cecilia; Holgersson, Georg; et al.
Digital multiplex immunofluorescence analysis identifies immune profiles in the tumor stroma associated with clinical outcome
Mezheyeuski, Artur; Bergsland, Christian; Backman, Max; Sjöblom, Tobias; et al.
30O Real-world prevalence of PD-L1 expression in locally advanced or metastatic non-small cell lung cancer (NSCLC): The global, multicentre EXPRESS study
Dietel, M.; Savelov, N.; Salanova, R.; Micke, Patrick; et al.
Digital pathology 2.0: a deep learning image analysis tool to identify lung cancer in human tissue samples
Micke, Patrick; Björk, L.; Backman, M.; Elfving, H.; et al.
Real-World Prevalence of PD-L1 Expression in Advanced NoneSmall-Cell Lung Cancer: The Global, Multicenter EXPRESS Study
Salanova, R.; Dietel, M.; Savelov, N.; Micke, Patrick; et al.
Reaching the limits of prognostication in non-small cell lung cancer: an optimized biomarker panel fails to outperform clinical parameters.
Grinberg, Marianna; Djureinovic, Dijana; Brunnström, Hans R R; Mattsson, Johanna Sofia Margareta; et al.
The integrative clinical impact of tumor-infiltrating T lymphocytes and NK cells in relation to B lymphocyte and plasma cell density in esophageal and gastric adenocarcinoma
Svensson, Maria C.; Warfvinge, Carl Fredrik; Fristedt, Richard; Hedner, Charlotta; et al.
Integrative analysis of genome-wide gene copy number changes and gene expression in non-small cell lung cancer
Jabs, Verena; Edlund, Karolina; Koenig, Helena; Grinberg, Marianna; et al.
Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity
Tanaka, Nobuyuki; Kanatani, Shigeaki; Tomer, Raju; Sahlgren, Cecilia; et al.
PD-L1 immunohistochemistry in clinical diagnostics of lung cancer: inter-pathologist variability is higher than assay variability
Brunnstrom, Hans; Johansson, Anna; Westbom-Fremer, Sofia; Backman, Max; et al.
Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer
Mathot, Lucy; Kundu, Snehangshu; Ljungström, Viktor; Svedlund, Jessica; et al.
RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer
Rao, Shuan; Sigl, Verena; Wimmer, Reiner Alois; Novatchkova, Maria; et al.
A pathology atlas of the human cancer transcriptome
Uhlen, Mathias; Zhang, Cheng; Lee, Sunjae; Sjöstedt, Evelina; et al.
Gene Expression Profiling of Large Cell Lung Cancer Links Transcriptional Phenotypes to the New Histological WHO 2015 Classification
Karlsson, Anna; Brunnström, Hans; Micke, Patrick; Veerla, Srinivas; et al.
Mutation Profiling by Targeted Next Generation Sequencing of an Unselected NSCLC Cohort
La Fleur, Linnea; Falk-Sörqvist, Elin; Smeds, Patrik; Sundström, Magnus; et al.
Establishing Reflex NGS Testing in NSCLC in a Regional Network of County Hospitals in Central Sweden
Isaksson, Johan; Willen, Linda; La Fleur, Linnea; Mindus, Stephanie; et al.
PD-L1 immunohistochemistry in clinical diagnostics: Inter-pathologist variability is as high as assay variability
Micke, Patrick; Johansson, Anna; Westbom-Fremer, Anna; Backman, Max; et al.
Integrative CAGE and DNA Methylation Profiling Identify Epigenetically Regulated Genes in NSCLC
Horie, Masafumi; Kaczkowski, Bogumil; Ohshima, Mitsuhiro; Matsuzaki, Hirotaka; et al.
Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel
Sandelin, Martin; Gruden, S.; Räsänen, Veera; Micke, Patrick; et al.
The clinical impact of tumour-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: A cohort study
Berntsson, Jonna; Svensson, Maria C.; Leandersson, Karin; Nodin, Bjorn; et al.
Antitumoral effect and reduced systemic toxicity in mice after intra-tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel
Grudén, Stefan; Sandelin, Martin; Rasanen, Veera; Micke, Patrick; et al.
Prognostic impact of tumour-associated B cells and plasma cells in epithelial ovarian cancer
Lundgren, Sebastian; Berntsson, Jonna; Nodin, Björn; Micke, Patrick; et al.
Transcriptome analysis of periodontitis-associated fibroblasts by CAGE sequencing identified DLX5 and RUNX2 long variant as novel regulators involved in periodontitis
Horie, Masafumi; Yamaguchi, Yoko; Saito, Akira; Nagase, Takahide; et al.
Inconsistent results in the analysis of ALK rearrangements in non-small cell lung cancer
Mattsson, Johanna Sofia Margareta; Brunnström, Hans; Jabs, Verena; Edlund, Karolina; et al.
The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling
Raja, Erna; Tzavlaki, Kalliopi; Vuilleumier, Robin; Edlund, Karolina; et al.
Epsin Family Member 3 and Ribosome-Related Genes Are Associated with Late Metastasis in Estrogen Receptor-Positive Breast Cancer and Long-Term Survival in Non-Small Cell Lung Cancer Using a Genome-Wide Identification and Validation Strategy
Hellwig, Birte; Madjar, Katrin; Edlund, Karolina; Marchan, Rosemarie; et al.
Various Antibody Clones of Napsin A, Thyroid Transcription Factor 1, and p40 and Comparisons With Cytokeratin 5 and p63 in Histopathologic Diagnostics of Non-Small Cell Lung Carcinoma
Tran, Lena; Mattsson, Johanna Sofia Margareta; Nodin, Björn; Jönsson, Per; et al.
Profiling cancer testis antigens in non-small-cell lung cancer
Djureinovic, Dijana; Hallström, Bjorn M.; Horie, Masafumi; Mattsson, Johanna Sofia Margareta; et al.
Prognostic impact of tumour-associated B cells and plasma cells in oesophageal and gastric adenocarcinoma
Fristedt, Richard; Borg, David; Hedner, Charlotta; Berntsson, Jonna; et al.
The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs
Micke, Patrick; Mattsson, Johanna Sofia Margareta; Djureinovic, Dijana; Nodin, Björn; et al.
Prognostic impact of tumour-infiltrating B cells and plasma cells in colorectal cancer
Berntsson, Jonna; Nodin, Björn; Eberhard, Jakob; Micke, Patrick; et al.
Prognostic impact of tumor-associated B-cells and plasma cells in esophageal and gastric adenocarcinoma
Fristedt, Richard; Hedner, Charlotta; Borg, David; Nodin, Björn; et al.
Fibroblast VEGF-receptor 1 expression as molecular target in periodontitis
Ohshima, Mitsuhiro; Yamaguchi, Yoko; Ambe, Kimiharu; Horie, Masafumi; et al.
Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer
Birgisson, Helgi; Edlund, Karolina; Wallin, Ulrik; Påhlman, Lars; et al.
The Identification of Therapeutic Targets in Lung Cancer Based on Transcriptomic and Proteomic Characterization of Cancer-Testis Antigens
Djureinovic, Dijana; Hallström, Björn; Mattsson, Johanna Sofia Margareta; La Fleur, Linnea; et al.
LRIG1 is a prognostic biomarker in non-small cell lung cancer
Kvarnbrink, Samuel; Karlsson, Terese; Edlund, Karolina; Botling, Johan; et al.
Prognostic impact of COX-2 in non-small cell lung cancer: A comprehensive compartment-specific evaluation of tumor and stromal cell expression
Mattsson, Johanna Sofia Margareta; Bergman, Bengt; Grinberg, Marianna; Edlund, Karolina; et al.
Mutation Profiling by Targeted Next-Generation Sequencing for Diagnostics and Patient Cohort Screening in FFPE NSCLC Samples
La Fleur, Linnea; Moens, Lotte; Falk-Sörqvist, Elin; Sundström, Magnus; et al.
The role of the p53 target Wig-1 in senescence and cancer
Jerhammar, Fredrik; Bersani, Cinzia; Djureinovic, Dijana; Micke, Patrick; et al.
The Crux of Molecular Prognostications in NSCLC: An Optimized Biomarker Panel Fails to Outperform Clinical Parameters
Djureinovic, Dijana; Grinberg, Marianna; Mattsson, Johanna Sofia Margareta; Edlund, Karolina; et al.
ALK Rearrangements in Non-Small Cell Lung Cancer: Comprehensive Integration of Genomic, Gene Expression and Protein Analysis
Mattsson, Johanna S. M.; Svensson, Maria A.; Hallström, Björn; Koyi, Hirsh; et al.
COX-2 Expression Does Not Predict Outcome of Celecoxib in Addition to Standard Chemotherapy in Advanced Non-Small Cell Lung Cancer
Gulyas, Miklos; Mattsson, Johanna S. M.; Lindgren, Andrea; Sederholm, Christer; et al.
Clinical Validation of HaloPlex Targeted Resequencing in Formalin-Fixed, Paraffin-Embedded (FFPE) Cancer Biopsies
Moens, Lotte. N.; Falk-Sörqvist, Elin; La Fleur, Linnea; Mattsson, Johanna; et al.
HaloPlex Targeted Resequencing for Mutation Detection in Clinical Formalin-Fixed, Paraffin-Embedded Tumor Samples
Moens, Lotte N. J.; Falk-Sörqvist, Elin; Ljungström, Viktor; Mattsson, Johanna; et al.
Identification of sample annotation errors in gene expression datasets
Lohr, Miriam; Hellwig, Birte; Edlund, Karolina; Mattsson, Johanna S. M.; et al.
Patients with Non-small Cell Lung Cancer Analyzed for EGFR: Adherence to Guidelines, Prevalence and Outcome
Sandelin, Martin; Berglund, Anders; Sundström, Magnus; Micke, Patrick; et al.
1p36 deletion is a marker for tumour dissemination in microsatellite stable stage II-III colon cancer
Mayrhofer, Markus; Kultima, Hanna Göransson; Birgisson, Helgi; Sundström, Magnus; et al.
Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer
Micke, Patrick; Mattsson, Johanna Sofia Margareta; Edlund, Karolina; Lohr, Miriam; et al.
The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling
Lindskog, Cecilia; Fagerberg, Linn; Hallstrom, Bjorn; Edlund, Karolina; et al.
Genomic and Transcriptional Alterations in Lung Adenocarcinoma in Relation to Smoking History
Karlsson, Anna; Ringner, Markus; Lauss, Martin; Botling, Johan; et al.
An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non-Small Cell Lung Cancer
Noguchi, Satoshi; Saito, Akira; Horie, Masafumi; Mikami, Yu; et al.
A systematic analysis of commonly used antibodies in cancer diagnostics
Gremel, Gabriela; Bergman, Julia; Djureinovic, Dijana; Edqvist, Per-Henrik; et al.
In situ mutation detection and visualization of intratumor heterogeneity for cancer research and diagnostics
Grundberg, Ida; Kiflemariam, Sara; Mignardi, Marco; Imgenberg-Kreuz, Juliana; et al.
The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer
Lohr, Miriam; Edlund, Karolina; Botling, Johan; Hammad, Seddik; et al.
Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis and tissue microarray validation
Botling, Johan; Edlund, Karolina; Lohr, Miriam; Hellwig, Birte; et al.
Genomic and Transcriptional Alterations in Lung Adenocarcinoma in Relation to EGFR and KRAS Mutation Status
Planck, Maria; Edlund, Karolina; Botling, Johan; Micke, Patrick; et al.
Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma
Staaf, Johan; Isaksson, Sofi; Karlsson, Anna; Jönsson, Mats; et al.
IGKC and Prognosis in Breast Cancer-Letter
Schmidt, Marcus; Micke, Patrick; Hengstler, Jan G.
Targeted Resequencing of Formalin-Fixed, Paraffin-Embedded (FFPE) Specimens for Mutation Diagnostics in Solid Tumors
Botling, Johan; Moens, Lotte N.; Sorqvist, Elin Falk; Sundström, Magnus; et al.
Interactions between LRIG proteins and LMO7 and the expression of LMO7 in human lung cancer.
Karlsson, Terese; Kvarnbrink, Samuel; Holmlund, Camilla; Botling, Johan; et al.
In vitro autoradiography of carcinoembryonic antigen in tissue from patients with colorectal cancer using multifunctional antibody TF2 and 67/68Ga-labeled haptens by pretargeting
Hall, Håkan; Velikyan, Irina; Blom, Elisabeth; Ulin, Johan; et al.
CD99 is a novel prognostic stromal marker in non-small cell lung cancer
Edlund, Karolina; Lindskog, Cecilia; Saito, Akira; Berglund, Anders; et al.
Consistent mutation status within histologically heterogeneous lung cancer lesions
Mattsson, Johanna Sofia Margareta; Imgenberg-Kreuz, Juliana; Edlund, Karolina; Botling, Johan; et al.
A comprehensive analysis of human gene expression profiles identifies stromal immunoglobulin kappa C as a compatible prognostic marker in human solid tumors
Schmidt, Marcus; Hellwig, Birte; Hammad, Seddik; Othman, Amnah; et al.
Data-driven unbiased curation of the TP53 tumor suppressor gene mutation database and validation by ultradeep sequencing of human tumors
Edlund, Karolina; Larsson, Ola; Ameur, Adam; Bunikis, Ignas; et al.
Immunoglobulin kappa chain as an immunologic biomarker of prognosis and chemotherapy response in solid tumors
Schmidt, Marcus; Micke, Patrick; Gehrmann, Mathias; Hengstler, Jan G
Allele-specific copy number analysis of tumor samples with aneuploidy and tumor heterogeneity
Rasmussen, Markus; Sundström, Magnus; Kultima, Hanna Göransson; Botling, Johan; et al.
Gene Copy Number Aberrations Are Associated with Survival in Histologic Subgroups of Non-small Cell Lung Cancer
Micke, Patrick; Edlund, Karolina; Holmberg, Lars; Göransson Kultima, Hanna; et al.
Traditional European Medicine: Hildegard von Bingen and beyond
Micke, O.; Büntzel, J.; Mücke, R.; Micke, Patrick; et al.
Targeted resequencing of candidate genes using Selector Probes
Johansson, Henrik; Isaksson, Magnus; Sörqvist, Elin Falk; Roos, F.; et al.
Fresh frozen tissue: RNA extraction and quality control
Botling, Johan; Micke, Patrick
Biobanking of fresh frozen tissue from clinical surgical specimens: transport logistics, sample selection, and histologic characterization.
Botling, Johan; Micke, Patrick
KRAS analysis in colorectal carcinoma: analytical aspects of Pyrosequencing and allele-specific PCR in clinical practice
Sundström, Magnus; Edlund, Karolina; Lindell, Monica; Glimelius, Bengt; et al.
TGF-beta Signaling in Gingival Fibroblast-Epithelial Interaction
Ohshima, M.; Yamaguchi, Y.; Matsumoto, N.; Micke, Patrick; et al.
Forkhead box F1 regulates tumor-promoting properties of cancer-associated fibroblasts in lung cancer
Saito, Roy-Akira; Micke, Patrick; Paulsson, Janna; Augsten, Martin; et al.
Gene Copy Number Aberrations are Associated with Survival in Histological Subgroups of Non Small Cell Lung Cancer
Micke, Patrick; Holmberg, L.; Edlund, Karolina; Lambe, M.; et al.
Complementary and alternative medicine in lung cancer patients: a neglected phenomenon?
Micke, O.; Buntzel, J.; Kisters, K.; Schafer, U.; et al.
CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth
Augsten, Martin; Hägglöf, Christina; Olsson, Eleonor; Stolz, Claudia; et al.
TA-MUC1 epitope in non-small cell lung cancer
Kuemmel, Andreas; Single, Kristjan; Bittinger, Fernando; Faldum, Andreas; et al.
Regulation of tyrosine phosphatases in the adventitia during vascular remodelling
Micke, Patrick; Hackbusch, Daniel; Mercan, Sibel; Stawowy, Philipp; et al.
bFGF rescues imatinib/STI571-induced apoptosis of sis-NIH3T3 fibroblasts.
Ohshima, Mitsuhiro; Yamaguchi, Yoko; Kappert, Kai; Micke, Patrick; et al.
Quantification of normal cell fraction and copy number neutral LOH in clinical lung cancer samples using SNP array data
Göransson, Hanna; Edlund, Karolina; Rydåker, Maria; Rasmussen, Markus; et al.
Predictive factors for the use of complementary and alternative medicine (CAM) in radiation oncology
Micke, Oliver; Bruns, Frank; Glatzel, Michael; Schoenekaes, Klaus; et al.
A novel strategy based on histological protein profiling in-silico for identifying potential biomarkers in urinary bladder cancer
Segersten, M. Ulrika; Edlund, E. Karolina; Micke, Patrick; de la Torre, Manuel; et al.
Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer
Paulsson, Janna; Sjöblom, Tobias; Micke, Patrick; Pontén, Fredrik; et al.
Impact of thawing on RNA integrity and gene expression analysis in fresh frozen tissue
Botling, Johan; Edlund, Karolina; Segersten, Ulrika; Tahmasebpoor, Simin; et al.
In vitro characterization of the cytokine profile of the epithelial cell rests of Malassez
Ohshima, Mitsuhiro; Yamaguchi, Yoko; Micke, Patrick; Abiko, Yoshimitsu; et al.
An open-label, prospective phase I/II study evaluating the immunogenicity and safety of a ras peptide vaccine plus GM-CSF in patients with non-small cell lung cancer
Meyer, Ralf G.; Korn, Stephanie; Micke, Patrick; Becker, Kai; et al.
In Situ Identification of Genes Regulated Specifically in Fibroblasts of Human Basal Cell Carcinoma
Micke, Patrick; Kappert, Kai; Ohshima, Mitsuhiro; Sundquist, Christina; et al.
Dynamic changes in the expression of DEP-1 and other PDGF receptor-antagonizing PTPs during onset and termination of neointima formation
Kappert, Kai; Paulsson, Janna; Sparwel, Jan; Leppänen, Olli; et al.
Biobanking of fresh frozen tissue: RNA is stable in nonfixed surgical specimens.
Micke, Patrick; Ohshima, Mitsuhiro; Tahmasebpoor, Simin; Ren, Zhi-Ping; et al.
Cytokine profile in synovial fluid from patients with internal derangement of the temporomandibular joint: a preliminary study.
Matsumoto, K; Honda, K; Ohshima, M; Yamaguchi, Y; et al.
Exploring the tumour environment: cancer-associated fibroblasts as targets in cancer therapy.
Micke, Patrick; Ostman, Arne
Laser-assisted cell microdissection using the PALM system.
Micke, Patrick; Östman, Arne; Lundeberg, Joakim; Ponten, Fredrik
A fluid cover medium provides superior morphology and preserves RNA integrity in tissue sections for laser microdissection and pressure catapulting
Micke, Patrick; Bjørnsen, Tone; Scheidl, Stefan; Strömberg, Sara; et al.
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate
Furuhashi, Masao; Sjöblom, Tobias; Abramsson, Alexandra; Ellingsen, Jens; et al.
Zinc-based fixative improves preservation of genomic DNA and proteins in histoprocessing of human tissues.
Wester, Kenneth; Asplund, Anna; Bäckvall, Helena; Micke, Patrick; et al.
Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications
Micke, Patrick; Basrai, Maryam; Faldum, Andreas; Bittinger, Fernando; et al.
Downregulation of bradykinin B2 receptor in human fibroblasts during prolonged agonist exposure
Blaukat, Andree; Micke, Patrick; Kalatskaya, Irina; Faussner, Alexander; et al.